Marya vial filling line is a new generation of water injection production linkage line developed on the basis of digesting and absorbing foreign advanced linkage lines, incorporating a number of patented technologies of the company, and aiming at the current situation of domestic injection production. It has advanced design, reasonable structure, high degree of automation, stable and reliable operation, high production efficiency, has realized mechatronics, and its performance has reached the current international advanced level, which can replace imported products.
The whole vial filling linkage line is divided into four working parts: cleaning, drying and sterilizing, filling and stoppering, capping, each single machine has its own specific function, which can accurately and reliably realize its functions. It can be used alone or in linkage production.
After the vials are poured, they enter the rough washing water tank for ultrasonic cleaning. After the rough washing is completed, they enter the fine washing process through the auger and the lifting cam. The inside of the bottle is cleaned with circulating water once, compressed air twice, compressed air once, injection water once, compressed air twice, and compressed air three times. At the same time, the outer wall of the bottle is washed with circulating water once and compressed air once. Then the bottle is taken out synchronously to complete the whole cleaning process.
After cleaning, vials are automatically fed into the tunnel-type sterilization dryer, they are dried and sterilized in a 100-level laminar flow airtight box. The vials are operated at a sterilization temperature of 320 degrees, and then enter the cooling zone to cool the vials. Then it is sent to the filling machine for filling and stoppering. After the vials are dried and sterilized, the entire filling process is carried out under the protection of 100-level laminar flow.
Marya vial filling production line adopts advanced production technology such as ultrasonic cleaning, multi-needle water-air alternate washing, hot air laminar flow drying and sterilization, multi-needle filling and wire drawing sealing, etc., with compact structure, safe and practical performance, stable and reliable function, small floor space, low needs of cleanroom, which greatly reduces the using cost of hvac system and the building cost plant construction.
This vial filling linkage line is suitable for 50ml, 100ml vials, 10ml, and 50ml vials, with few specifications and easy replacement and adjustment. It enhances the ability to adapt to changes in market demand, improves equipment utilization, reduces use costs, and improves production efficiency.
The single machine of the whole filling unit is controlled by a PLC programmable human-machine interface, which can be controlled by linkage and stand-alone operation, which can realize the monitoring of production status and production site conditions, and automatically shut down in case of failure, ensuring the normal operation of the whole vial filling line.
The parts in contact with the liquid medicine are made of 316L stainless steel, high-quality silicone tubes or glassware, and the parts covered on the outside are made of 304-2B stainless steel plates. In terms of equipment material selection, it fully complies with the requirements of GMP specifications.
In terms of control operation, it can also be configured according to the special needs of users. According to the situation of the factory building, the bottle conveying mesh belt is added to automatically input the vials and avoid manual handling in the clean area. It can realize the whole process of production in the clean area without the turnover of the turntable, and the unpacking and loading of the bottles and the loading of the finished products are all completed in the general area. Simplify the cleaning and sterilization process of the turntable, reduce the cross-contamination of people and flows in the clean area, and make the whole unit more in line with GMP requirements.
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